Ophthalmic Therapeutic Innovation
Ophthalmic Therapeutic Innovation
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    • Home
    • About OTI
      • Mission
      • Vision
      • History
      • Contact Us
    • Pipelines & Partners
    • Breakthrough Discovery
    • Glaucoma
    • Team
    • Publications
    • News
  • Home
  • About OTI
    • Mission
    • Vision
    • History
    • Contact Us
  • Pipelines & Partners
  • Breakthrough Discovery
  • Glaucoma
  • Team
  • Publications
  • News

Glaucoma


Pathology

Glaucoma is the leading cause of irreversible blindness in people over 50 years of age. It is a neurodegenerative disease of the eye associated with many risk factors. Its initial diagnosis is associated with increased pressure within the eye called intraocular pressure (IOP).  Elevated IOP levels over time can damage the optic nerve and cause the demise of retinal ganglion cells (RGCs).  Increased IOP is due to impaired trabecular meshwork (TM)  to efficiently drain the aqueous humor fluid.  The root causes of glaucoma can be traced to the loss of TM sensing cells and IOP diurnal irregularities. 



Epidemiology

 Incidence of glaucoma is expected to  increase in the US and worldwide due to increasing global aging populations. In 2024, there are 3 million cases of glaucoma in the US alone and 80 million cases worldwide.  The latter is expected to rise to 112 millions  by 2040.  In the US, African Americans are more adversely affected by glaucoma than other groups.  Compare to Caucasians,  they are 15 times more likely to experience visual impairment linked to glaucoma and 6 to 8 times more likely to experience blindness because of glaucoma. 

Current treatments

While there is no cure for glaucoma,  there are a number of treatments that can reduce IOP levels  and slow disease progression and vision loss. These include eyedrops or sustained release implant that contain pharmacological agents such as prostaglandins, Rho kinase inhibitors, nitric oxide, cholinergic agents, alpha-adrenergic agonists, and beta blockers.  For non-responders to eyedrop medication, alternative treatments include  Selective Laser Trabeculoplasty (SLT) ,  Minimally Invasive Glaucoma Surgery (MIGS) ,  drainage implant (aqueous shunt), or  trabeculotomy. 

A Pioneer of Using Big Data for IP Creation, Regulatory Submission, and Solving the 90% Failure in Drug Development.

    Please donate to end glaucoma blindness.

    First Curative Therapy (eye drops) for Refractory Glaucoma.

    Ophthalmic Therapeutic Innovation (OTI) LLC is on a mission to revolutionize the treatment of glaucoma and prevent blindness. Our groundbreaking therapy, OTI-2024/Trabodenoson, represents a significant step forward as the first tissue rejuvenation drug aimed at addressing refractory glaucoma. With a robust patent portfolio and a submitted New IND to the FDA for Phase 3 trials, we are poised for success. However, we need your support to bridge a funding gap of $100K for crucial patent filings and operational costs over the next six months. Your contribution will directly impact our ability to move forward with our innovative research and bring this life-changing therapy to those in need. Visit our website for more information and consider donating today. Every dollar counts in the fight against glaucoma. Thank you for your support! Donation link:  https://gofund.me/521568a0

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