Ophthalmic Therapeutic Innovation
Ophthalmic Therapeutic Innovation
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    • Home
    • About OTI
      • Mission
      • Vision
      • History
      • Contact Us
    • Pipelines & Partners
    • Breakthrough Discovery
    • Glaucoma
    • Team
    • Publications
    • News
  • Home
  • About OTI
    • Mission
    • Vision
    • History
    • Contact Us
  • Pipelines & Partners
  • Breakthrough Discovery
  • Glaucoma
  • Team
  • Publications
  • News

OTI breakthrough discoveries in glaucoma disease

The trabecular meshwork and glaucoma

Rate Limiting Root Cause of Glaucoma Vision Loss

Problem of glaucoma lies at the outflow engine broken underpinning the pressure sensor dysfunction along with pressure sensing cell loss. In clinics, it reflects the IOP irregularities (random spikes) which kills the neurons at the retina. To protect the pressure sensing cells is to protect the retinal ganglion cell health in patients with glaucoma. 


Inventor; Tina Guanting Qiu. US Publication #US2024/00024348A1 and PCT 1 # PCT/18/356,875. 

Figure adapted from Minimally Invasive Glaucoma Surgery, 2021 at the courtesy by Prof. Keith Barton.  

Discovery of chief IOP regulator

Pressure Sensor acts as chief IOP regulator

 The pressure sensor is the chief regulator of IOP, composed of pressure sensing cells and the underlying basement membrane, similar in relation to RPE and its underlying Bruch’s membrane. Like RPE and cornea endothelium cells, the pressure sensing cells derive from the neural crest during embryonic development, lack of self-renew in adulthood. The pressure sensing cell loss reaches to a certain threshold (unknow, e.g. 60% loss), patients become poor or non-responders to current IOP lowering medication at which point an invasive surgery (e.g. tube shunt) becomes inevitable, however that fails at 50% in 3-5 years. Early intervention to protect the pressure sensing cell health is of strategic importance.   


Figure adapted from Clin Exp Ophthalmol. 2022 at the courtesy by Prof. KE Keller and Prof. DM Peters. 

OTI-2024 Dual Mode of Actions

OTI-2024 is a new MMP therapeutic agent

 OTI-2024 is the best in class and first in class adenosine A1 receptor agonist (small molecule).  OTI-2024 has unique dual MoAs (A1R+MMP Enhancer),  offers both cytoprotecting to the pressure sensing cells and trabecular meshwork (TM) rejuvenation (via ECM remodeling by the MMP-14), as well as a fast mode IOP lowering (bell shape) via Muscarinic 2 activation. These attributes make OTI-2024 as the Best drug in MMP-based therapeutic domain.


OTI-2024 MMP therapeutics

OTI-2024 has the potential to reverse and stop glaucoma disease progression via TM rejuvenation.

OTI-2024 represents a new MMP platform therapy to offer the first curative solution for treating non-responders in advanced stage glaucoma  due to its superiority of clinical safety and MMP therapeutic potency.  It has the potential to fully  stop the vision loss through MMP trabecular meshwork rejuvenation for early to late stage glaucoma.  

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